Feasibility of resuscitative transesophageal echocardiography at out-of-hospital emergency scenes of cardiac arrest

Guidelines recommend the use of ultrasound in cardiac arrest. Transthoracic echocardiography, has issues with image quality and by increasing hands-off times during resuscitation. We assessed the feasibility of transesophageal echocardiography (TEE), which does not have both problems, at out-of-hospital cardiac arrest (OHCA) emergency scenes. Included were 10 adults with non-traumatic OHCA in Vienna, Austria. An expert in emergency ultrasound was dispatched to the scenes in addition to the resuscitation team. Feasibility was defined as the ability to collect specific items of information by TEE within 10 min. Descriptive statistics were compiled and hands-off times were compared to a historical control group. TEE examinations were feasible in 9 of 10 cases and prompted changes in clinical management in 2 cases (cardiac tamponade: n = 1; right ventricular dilatation: n = 1). Their mean time requirement was 5.1 ± 1.7 (2.8–8.0) min, and image quality was invariably rated as excellent or good during both compressions and pauses. No TEE-related complications, or interferences with activities of advanced life support were observed. The hands-off times during resuscitation were comparable to a historical control group not involving ultrasound (P = 0.24). Given these feasibility results, we expect that TEE can be used routinely at OHCA emergency scenes.


Patients characteristics
Inclusion in the study was confined to adult patients who suffered cardiac arrest and were treated by advanced life support-including the use of an endotracheal tube to secure the airway-at OHCA emergency scenes.Patients were excluded if they required immediate transport to a hospital under cardiopulmonary resuscitation (i.e.due to pregnancy, traumatic cardiac arrest, persistent ventricular fibrillation, or for extracorporeal membrane oxygenation) or if TEE was contraindicated (i.e.known esophageal stenosis, esophageal tumor, recent upper gastrointestinal surgery).

Interventions and measurements
The standard management for OHCA within the city of Vienna is to dispatch an advanced-life-support ambulance with two emergency technicians, a doctors' car staffed with an emergency physician and an emergency technician, and a field supervisor (a senior emergency technician) to the scene of the emergency.For the purpose of our investigation, an additional study team was dispatched, which comprised both an emergency technician and an emergency physician trained in TEE.The study team was available from 7:00 am to 7:00 pm on six days during the study period and, on these days, was dispatched to all calls, for presumed adult out of hospital cardiac arrest.
The primary responsibility for treatment rested with the routinely dispatched team, while the study team was in charge of the TEE examination only.However, when they arrived to the scene first, they immediately started treatment and handed over to the routinely dispatched team upon their arrival.TEE was initiated once the required measures of advanced life support, including endotracheal intubation, were in place.
A portable ultrasound unit was used with its proprietary transesophageal transducer (Sonosite Edge II and Sonosite TEExi ; FUJIFILM Sonosite, Amsterdam, Netherlands).With the probe inserted, a mid-esophageal four-chamber, a mid-esophageal three-chamber, and a trans-gastric short-axis view were obtained to collect four items of information as described below (see Primary outcome below).A member of the study team measured the time requirement for the TEE examination from the team's arrival and intubation in place until the four items of information had been collected.This information was then communicated to the standard team, who, depending on the situation and using their discretion, decided whether the TEE probe should be removed (n = 3), TEE continued throughout resuscitation (n = 4), or the patient transported to the hospital (n = 2).
Image quality was rated by the TEE operator on the same five-point scale used for grades throughout the Austrian education system, thus being a natural reference for decisions under time pressure (1 = great/excellent; 2 = good; 3 = fair; 4 = poor; 5 = inadequate).These ratings were obtained both during chest compressions and during pauses.
A member of the study team documented any potential complications related to the TEE procedure such as oropharyngeal injury, dental trauma, malposition of the probe, or inadvertent extubation.The field supervisor, an emergency technician in charge of quality assurance, watched over the entire scenery and documented any effects that the conduct of the TEE examination may have had on the emergency team's performance.

Outcomes
Primary outcome Feasibility of TEE to guide cardiopulmonary resuscitation at out-of-hospital emergency scenes of cardiac arrest was the primary outcome of this study.The criterion of feasibility was considered to be met when the TEE examination could actually be performed and the following items of information collected within 10 min:

Hands-off times versus a historical control group
Hands-off times were evaluated based on the patient impedance records kept in the internal memory of the defibrillators (Lifepak 15; Physio-Control, Redmond, WA, USA).These hands-off data were compared to a historical control group of patients from the Vienna Cardiac Arrest Registry whose management had not involved pointof-care ultrasound.To this end, each patient who could be examined by TEE was matched with two historical controls based on age, gender, body mass index, initial heart rhythm, setting of the emergency, total duration of cardiopulmonary resuscitation, and use of a mechanical chest compression system (LUCAS®).Hands-off times are expressed in absolute terms and as percentages of the total resuscitation times.

Analysis
No sample size calculation was performed for the purpose of this feasibility study, also because the ethics committee had ruled an limit of 10 patients.Statistical software (SPSS Statistics 27.0; IBM, Armonk, NY, USA) was used for descriptive data analysis (mean values, standard deviations, percentages) and for a t-test comparing the hands-off times between the study population and the historical control group.Data are presented as mean ± SD (min-max).

Ethical Approval
Patient enrolment was preceded approval by the institutional review board (Ethics Committee of the Medical University of Vienna, Ref. Nr. 1718/2019).

Results
The study team was dispatched to 19 emergency scenes of suspected OHCA (Fig. 1).Six of these patients were dead by the time the first team arrived, so that cardiopulmonary resuscitation attempts were stopped without a need to perform a TEE examination.In two patients, resuscitation was not initiated because the suspicion of cardiac arrest was not confirmed.One patient required a supraglottic airway device and could not be included.Table 1 gives an overview of pertinent patient data for the 10 cases that eventually were included as the upper limit set by the ethics committee.Nine of these met the feasibility criterion that the TEE examination could be completed and the required items of information obtained within 10 min.In one patient, the planned TEE examination was prevented by a power failure of the ultrasound unit.The average time requirement for completion of the TEE examination was 5.1 ± 1.7 (2.8-8.0)min.
Average fraction of hands-off time of the total resuscitation time was 10 ± 7 (2-25) % when TEE was performed.This was statistically comparable to a result of 9 ± 5 (2-21) % in the historical control group (P = 0.24) (Table 1).
In three cases, the TEE findings prompted changes in clinical management.One return of spontaneous circulation was detected before clinical signs became apparent, resulting in discontinuation of the cardiopulmonary resuscitation before the next rhythm check.The second one of these patients received thrombolysis for suspected www.nature.com/scientificreports/pulmonary embolism-with a return of spontaneous circulation 30 min later-after massive dilatation of the right ventricle had been visualized (Fig. 2).The third patient died, despite an attempt at pericardial drainage, after the TEE had revealed pericardial tamponade (Fig. 3).
No complications were noted as a result of the TEE examinations.According to the field supervisor, the standard emergency team's performance was, in one case (the one just mentioned), affected by an unexpected ultrasound finding of massive hemorrhagic pericardial effusion, in that the team had difficulty deciding whether chest compressions should be continued or suspended during the attempted relief of the tamponade.In this case, the fractional hands within the first 5 min after intubation (when the pericardial effusion was detected) was 13% and fractional hands-off time within 10 min after intubation (when the tamponade was attempted to be relieved) was 34%.This suggests, that rather the therapeutic intervention for this unexpected intervention, than the TEE exam itself caused the rather long hands-off time in this case.Table 2 summarizes the results for the TEE-related outcome parameters.Image quality as rated by the TEE operator was excellent (best out of five possible scores) in six cases and good (second-best out of five possible scores) in three cases during ongoing chest compressions.During pauses, the ratings were likewise excellent in six and good in three cases.In other words, the ratings of image quality did not differ or change between ongoing cardiopulmonary resuscitation and intermittent pauses.

Discussion
Our study demonstrates the feasibility of TEE to guide treatment of cardiac arrest at OHCA emergency scenes.In experienced hands, TEE allows reversible causes of cardiac arrest to be diagnosed in these situations without adding any adverse effects and without being disruptive to simultaneous activities of resuscitation.
Focused ultrasound examinations are today routinely used by emergency and intensive care physicians both in most hospitals and in prehospital settings 5 .There are, however, limitations to transthoracic electrocardiography in situations of cardiac arrest.Notably in mechanically ventilated patients, its image quality is inferior compared to TEE [9][10][11] .In addition, the time windows for transthoracic ultrasound are confined to pauses in chest compression (e.g. for rhythm checks).Studies have indicated a doubling of hands-off times, which implies significant interruptions in chest compressions, by transthoracic electrocardiography 7,8 .This drawback was not observed with TEE 16 .
The present study, too, yielded hands-off times that were statistically comparable to a historical control group not involving point-of-care ultrasound.Also, the proportion of cases in which TEE prompted changes in clinical  management was considerable.Arguably, these findings of severe right ventricular dilatation (n = 1), pericardial effusion (n = 1), or return of spontaneous circulation (n = 1) might also have been detectable by transthoracic echocardiography.TEE is, however, known from previous studies to offer superior identification of relevant pathologies in critically ill, ventilated patients 9,10 .As additional benefits, chest compressions can be viewed and optimized for effectiveness in real time, and the TEE probe can be left in situ after return of spontaneous circulation for continuous visualization of cardiac function in this precarious phase 14,15,[17][18][19][20][21][22] .Despite these potential benefits, the TEE probe was withdrawn in 3 cases.In one case, the focus was switched to transport priority under CPR.In two cases, the treating physicians did not believe, that keeping the probe in situ would add additional information and therefore should be removed.We invariably achieved excellent or good image qualities during chest compressions in a study environment that included an extra emergency physician with TEE expertise.An expert was added because the skill to conduct TEE safely and effectively, which does require special training, is not a given amongst prehospital emergency physicians in our city 23 .While this reliance on extra staff might be considered a limitation of our study, the learning curve for TEE in intubated patients has not been found to be overly steep, with 20-50 procedures being required for successful examinations in 80-100% of cases 24,25 .
In-hospital settings have been shown previously to enable safe application of TEE by emergency physicians and intensive care specialists, frequently disclosing valuable information that prompted changes in clinical management 13,26 .Based on what evidence is currently available, we expect that TEE can soon be implemented at OHCA emergency scenes, maybe without a need to dispatch extra staff.We also expect the findings of the present investigation to set a departure point for larger-scale outcome studies.
In summary, this study demonstrates both the feasibility of TEE examinations at OHCA emergency scenes in a vast majority of cases and the ability of findings thus obtained to prompt changes in clinical management decisions.Further studies are needed to address in greater detail questions related to the training of operators, implementation of TEE in routine care, impact on hands-off times, and improvement of patient outcomes.

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Myocardial activity and aortic valve opening during compression pauses • Size and function of the left ventricle (rough estimate) • Size and function of the right ventricle (rough estimate) • Presence or absence of pericardial effusion or tamponade Secondary outcomes • Time requirements for the TEE examinations (duration until completion) • Image quality as rated by the TEE operator during compressions and pauses Vol.:(0123456789) Scientific Reports | (2023) 13:20085 | https://doi.org/10.1038/s41598-023-46684-xwww.nature.com/scientificreports/Changes in clinical management decisions as a result of TEE findings • Complications of TEE examinations and effects on the team's performance • Interference of TEE examinations with activities of advanced life support • Effect of TEE examinations on hands-off times during resuscitation

Figure 1 .
Figure 1.CONSORT diagram of the study design.

Figure 2 .
Figure 2. Mid-esophgeal four-chamber view obtained by TEE during cardiopulmonary resuscitation of patient no.10.

Figure 3 .
Figure 3. Mid-esophgeal four-chamber view obtained by TEE during cardiopulmonary resuscitation of patient no. 4.